First-Pass Arrival Interval of Ultrasound Contrast Medium in the Hepatic Artery and Portal Vein as a Marker for Assessment of Liver Transplant Recipients |
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| Institution: | 1. Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan;2. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;3. Division of Transplantation Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;4. Division of Pediatric Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;5. Department of Medical Imaging and Radiological Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan;6. Department of Radiology, Yee Zen General Hospital, Taoyuan, Taiwan;1. Department of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea;2. Biomedical Research Institute, Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea;1. Department of Urology, Guangdong Provincial People''s Hospital (Guangdong Academy of Medical Sciences), School of Medicine, South China University of Technology, Guangzhou, Guangdong, China;2. Shantou University Medical College, Shantou, Guangdong, China;3. Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China;1. Department of Medicine, King Saud University, College of Medicine, Liver Disease Research Center, Riyadh, Saudi Arabia;2. Liver Transplantation and Hepatobiliary-Pancreatic Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia;3. QualityStat, Morangis, France;4. Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland;5. Department of Internal Medicine, Minia University, Egypt;1. Department of Hematology, Pingxiang Municipal People''s Hospital of Jiangxi Province, Pingxiang, China;2. Department of Hematology, The Affiliated Huai''an Hospital of Xuzhou Medical University and The Second People''s Hospital of Huai''an, Huai''an, Jiangsu Province, China;3. National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation of Soochow University, Suzhou, China |
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| Abstract: | BackgroundThis study measures the first-pass arrival times in the hepatic artery and portal vein of the transplanted liver using contrast-enhanced ultrasound (CEUS) and assess its correlation with graft performance in the early posttransplant period.MethodsThis study evaluated 35 liver transplant recipients who underwent CEUS examination within 1 month of transplant surgery. CEUS under contrast-specific harmonic imaging mode were recorded for 60 seconds immediately after intravenous administration of microbubble ultrasound contrast medium (Sonazoid, GE Healthcare, Oslo, Norway). The recorded video clips were reviewed by 2 readers to determine the first-pass arrival times in the hepatic artery and portal vein, and the difference between the 2 was defined as the arterial-portal arrival interval (APAI). Laboratory data on the same date of CEUS examination were collected as indicators to correlate with APAI.ResultsThe intra- and inter-rater reliability for APAI measurement were excellent, with intraclass correlation coefficients > .95. The mean APAI was 4.5 ± 1.8 seconds (range, 2.0-10.5 seconds). The APAI was positively correlated with the serum total bilirubin level (r = 0.357, P = .035) and negatively correlated with the platelet count (r = ?0.354, P = .037). At the 5 second cutoff point, a total serum bilirubin of >8 mg/dL was reported in 5 of 11 patients (45.4%) with APAI of >5 seconds and in only 3 of 24 patients (12.5%) with APAI of <5 seconds (P < .05).ConclusionsThe APAI is a quantitative marker that links the hemodynamics and the clinical status of the liver graft. |
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