静脉化疗联合PEI治疗乳腺癌术后肝转移15例疗效观察

目的:观察静脉化疗联合经皮穿刺无水乙醇瘤内注射(PEI)治疗乳腺癌伴肝转移的疗效。方法:15例均为乳腺癌术后并确诊有肝转移,给予化疗(TP方案):紫杉醇135 mg/m2,第1天,静脉输注;顺铂40 mg/d,第2~4天,静脉输注。28 d为1周期,均用4疗程以上。同时化疗前、后肝转移瘤灶给予彩超引导下PEI治疗,每个病灶最少2次,最多4次。结果:完全缓解3例,部分缓解12例,有效率100%;均存活6个月以上,10例病死患者中最长存活22个月。不良反应为食欲低下、恶心呕吐、白细胞减少、肝功能一过性异常和穿刺部位疼痛。结论:PET和TP方案静脉全身化疗对乳腺癌术后肝转移有一定疗效。

Clinical observation of systemic chemotherapy combined with percutaneous ethanol injection treatment on breast carcinoma postoperation with liver metastasis

Objective：To explore the efficacy of systemic chemotherapy combined with percutaneous ethanol injection（PEI） treatment on breast carcinoma postoperative patients with liver metastasis. Methods：Fifteen cases were all breast cancer postoperative patients with liver metastasis. All patients were received paclitaxel toisplatin （TP） protocol. The treatment included systemic chemotherapy of paclitaxel 135 mg/m2 intravenous injection on first day followed by cisplatin 30 mg/d for 3 days ,28 days for one cycle, and each patient was experienced for more than 4 courses. Metastatic tumor foci of liver was also received therapy of PEI under ultrasound-guided. Each foci was experienced treatment for 2 to 4 times. Results：Three cases were complete remission, 12 cases were partial remission,the total response rate was 100%. All patients survived for more than 6 months,in 10 cases of death, one patient survived for 22 months. Adverse reaction included lower appetite, nausea, vomiting, neutropenia, transient liver function abnormalities and the puncture site pain. Conclusions ： The combination of PET and systemic chemotherapy by TP protocol may be an effective treatment to postoperative patients with breast carcinoma and hepatic metastasis.