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The effect of sRAGE-Fc fusion protein attenuates inflammation and decreases mortality in a murine cecal ligation and puncture model |
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| Authors: | Su Jin Jeong Beom Jin Lim Sungha Park Donghoon Choi Hye Won Kim Nam Su Ku Sang Hoon Han Chang Oh Kim Jun Yong Choi Young Goo Song June Myung Kim |
| Affiliation: | 1. Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea 2. Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea 3. Division of Cardiology, Cardiovascular Center, Yonsei University College of Medicine, Seoul, Republic of Korea |
| Abstract: | ObjectiveInhibition of the receptor for advanced glycation end products (RAGE) may attenuate the systemic inflammatory response and ensuing severe sepsis. We report an investigation into the effect of soluble RAGE (sRAGE)-Fc fusion protein in severe sepsis induced by a cecal ligation and puncture (CLP) procedure.Materials and methodsThe experiment was performed using CLP control mice, mice treated with 0.5 or 1.0?μg sRAGE-Fc fusion protein, and sham surgery mice.ResultsSurvival benefits over the CLP control group were evident (P?=?0.036) in mice given 1.0?μg sRAGE-Fc fusion protein. In addition, the pulmonary inflammation score in the sRAGE-Fc fusion protein-treated group was significantly lower than that in the CLP control group (P?P?P?Conclusions sRAGE-Fc fusion protein has beneficial effects in a standard murine model of polymicrobial, intra-abdominal severe sepsis. |
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