首页 | 本学科首页   官方微博 | 高级检索  
     

子痫前期患者胎盘组织中松弛素受体的表达
引用本文:Wang YQ,Li J,Yang Z. 子痫前期患者胎盘组织中松弛素受体的表达[J]. 中华妇产科杂志, 2008, 43(4): 269-271
作者姓名:Wang YQ  Li J  Yang Z
作者单位:1. 北京大学第三医院妇产科,100083
2. 中国医科大学附属盛京医院妇产科
摘    要:目的 探讨子痫前期患者胎盘组织中松弛素受体LGR7表达与子痫前期发病的关系.方法 应用链霉菌抗生物素蛋白-过氧化物酶连接法和RT-PCR技术检测20例正常孕妇(正常组)及26例重度子痫前期孕妇(子痫前期组)胎盘组织中松弛素受体LGR7蛋白及mRNA的表达.结果 (1)两组孕妇的胎盘组织中均有松弛素受体LGR7表达,主要定位于胎盘绒毛滋养细胞的细胞膜上,在细胞滋养细胞、合体滋养细胞中都有较高的表达水平.(2)正常组胎盘组织中松弛素受体LGR7蛋白的表达水平为0.912±0.003,子痫前期组为0.625±0.037,两组比较,差异有统计学意义(P<0.01).(3)正常组胎盘组织中松弛素受体LGR7 mRNA表达水平为0.776±0.021,子痫前期组为0.393±0.075,两组比较,差异有统计学意义(P<0.01).结论 子痫前期患者胎盘组织中松弛素受体表达水平下降,可能与子痫前期的发病有关.

关 键 词:先兆子痫  胎盘  受体,G-蛋白偶联  受体,肽

Expression of relaxin receptor in placental tissues of normal pregnancy and pre-eclampsia
Wang Yong-Qing,Li Jun,Yang Zi. Expression of relaxin receptor in placental tissues of normal pregnancy and pre-eclampsia[J]. Chinese Journal of Obstetrics and Gynecology, 2008, 43(4): 269-271
Authors:Wang Yong-Qing  Li Jun  Yang Zi
Affiliation:Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, China.
Abstract:OBJECTIVE: To study the location and level of relaxin receptor in placenta tissues of pre-eclampsia and normal pregnancy, and the relationship of relaxin receptor with pre-eclampsia. METHODS: Twenty-six placenta tissue samples from pregnant women with severe preeclampsia (study group), and 20 samples from normal pregnancies (control group) were obtained. We detected the expression of relaxin receptor by immunohistochemistry and the expression of relaxin receptor mRNA by RT-PCR. RESULTS: In the placenta of control and preeclampsia groups, the leucine-rich repeat-containing G protein-coupled receptor (LGR7) was positively expressed. Relaxin receptor was located in the membrane of trophoblast cells. There were both strong signals on cytotrophoblastic cells and syncytiotrophoblast. The level of relaxin receptor in the control group was 0.912 +/- 0.003, and 0.625 +/- 0.037 in the preeclampsia group. The difference between the two groups was obvious (P < 0.01). In the control group, the level of relaxin receptor mRNA was 0.776 +/- 0.021; in the preeclampsia group, it was 0.393 +/- 0.075. The difference was obvious (P < 0.01). CONCLUSION: Decrease in the expression of relaxin receptor at placenta is related with the occurrence and development of preeclampsia.
Keywords:Pre-eclampsia  Placenta  Receptors,G-protein-coupled  Receptors,peptide
本文献已被 万方数据 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号