| 肿瘤抗原MAGE-3 CTL预测表位的计算机分子模拟研究 |
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| 引用本文： | 贾正才,吴玉章,万瑛. 肿瘤抗原MAGE-3 CTL预测表位的计算机分子模拟研究[J]. 第三军医大学学报, 2000, 22(10): 937-939 |
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| 作者姓名： | 贾正才 吴玉章 万瑛 |
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| 作者单位： | 第三军医大学基础医学部全军免疫学研究所,重庆,400038;第三军医大学基础医学部全军免疫学研究所,重庆,400038;第三军医大学基础医学部全军免疫学研究所,重庆,400038 |
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| 基金项目： | 中国科学院资助项目,39900134, |
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| 摘 要： | 目的 从理论上分析预测表位与ＨＬＡ－Ａ２分子的结合情况及其为ＨＬＡ－Ａ２限制性ＣＴＬ表位的可能性。方法 应用计算机分子模拟的方法,建立ＭＡＧＥ－３４个ＣＴＬ预测表位的ＨＬＡ－Ａ２结合三维结构和各多肽与ＨＬＡ－Ａ２分子所形成复合的三维结构。结果 ４个预测表位的三维结构完全符合ＨＬＡ－Ａ２限制性ＣＴＬ表位的结构要求,且都能与ＨＬＡ－Ａ２分子结合。结论 ４个ＣＴＬ预测表位为ＨＬＡ－Ａ２限制性ＣＴＬ表位的
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| 关 键 词： | 肿瘤抗原 MAGE-3 细胞毒性T淋巴细胞表位 分子模拟 |
| 文章编号： | 1000-5404(2000)10-0937-03 |
| 修稿时间： | 2000-08-04 |
Study of molecular models of predicted CTL epitopes derived from the tumor antigen MAGE-3 |
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| JIA Zheng-cai,WU Yu-zhang,WAN Ying. Study of molecular models of predicted CTL epitopes derived from the tumor antigen MAGE-3[J]. Acta Academiae Medicinae Militaris Tertiae, 2000, 22(10): 937-939 |
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| Authors: | JIA Zheng-cai WU Yu-zhang WAN Ying |
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| Abstract: | Objective To analyze the binding of CTL epitope candidates to the HLA A2 molecule and the possibility of them being HLA A2 restricted CTL epitopes. Methods The molecular models of CTL epitope candidates bound to the HLA A2 molecule and of the HLA A2 peptide complex were established by computer molecular modeling. Results The three dimensional configurations of four HLA A2 binding peptides were compatible with those of HLA A2 restricted CTL epitopes and they could bind to HLA A2 molecule. Conclusion It is suggested that the four peptides may be the CTL epitopes restricted by HLA A2 molecule. |
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| Keywords: | tumor antigen MAGE 3 cytotoxic T lymphocyte epitope molecular modeling |
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