Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder. |
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| Authors: | Chi-Un Pae Alessandro Serretti Laura Mandelli Hye-Sook Yu Ashwin A Patkar Chang-Uk Lee Soo-Jung Lee Tae-Youn Jun Chul Lee In-Ho Paik Jung-Jin Kim |
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| Affiliation: | Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea. |
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| Abstract: | We investigated a possible association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). Five SNPs within DTNBP1 (rs3213207, rs1011313, rs2005976, rs760761, and rs2619522) were genotyped for 151 patients with BID and 478 controls. We observed a significant protective association of the haplotype A-C-G-T-A (all SNPs, P = 0.00016) and particularly G-T-A (the last three SNP, P = 0.00007) within DTNBP1 variants investigated. Single marker and subgroup (e.g., psychotic features, age at onset, family history, etc.) analyses showed no significant association. Although the association was due to a small number of subjects, specific DTNBP1 haplotypes, previously associated with schizophrenia, may be also associated with BID. Adequately powered studies from different ethnicities will be necessary to confirm our findings. |
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