Efficacy of nimodipine in the prophylaxis of migraine |
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Authors: | H Havanka-Kanniainen E Hokkanen VV Myllylä |
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Institution: | Department of Neurology, University of Oulu, SF-90220, Oulu 22, Finland |
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Abstract: | The efficacy of nimodipine in the prophylaxis of migraine was assessed in a double-blind, placebo-controlled, cross-over study carried out on 33 patients, 20 of whom suffered from classic and 13 from common migraine. Four patients dropped out, but not as a result of the side effects of the drug. The duration of drug treatment was 8 weeks. The dosage used was 30 mg four times daily. Nimodipine proved to be better than placebo, the number of migraine attacks and severity of headache showing a significant reduction. The drug was well tolerated and no marked side effects were noted. The results suggest that nimodipine is a useful new prophylactic drug for migraine, but further studies are needed before its final value can be evaluated. |
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Keywords: | Calcium antagonist migraine migraine prophylaxis nimodipine |
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