| PTEN基因单核苷酸多态性与乳腺癌的关系 |
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| 引用本文： | 赵中华,陈绍水,董新军,宁方玲,李绵利,党诚学. PTEN基因单核苷酸多态性与乳腺癌的关系[J]. 现代肿瘤医学, 2012, 20(7): 1347-1349 |
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| 作者姓名： | 赵中华 陈绍水 董新军 宁方玲 李绵利 党诚学 |
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| 作者单位： | 1. 滨州医学院附属医院肿瘤科,山东滨州,256603
2. 西安交通大学医学院第一附属医院肿瘤外科,陕西西安,710061 |
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| 摘 要： | 目的:研究PTEN基因-9C/G单核苷酸多态性与中国汉族女性人群乳腺癌之间的相关性。方法:采用基于人群的病例-对照研究,以聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法进行基因分型,检测210例中国汉族女性乳腺癌患者和210例健康女性的PTEN基因-9C/G多态性。结果:PTEN基因-9C/G位点(rs11202592)多态性基因型分布频率在两组间比较无显著性差异(P=0.862)。PTEN基因-9C/G单核甘酸多态性不同基因型间在ER、Her-2表达上无显著性差异(P>0.05)。结论:PTEN基因-9C/G位点多态性与中国汉族女性乳腺癌易感性无明显关联,ER、HER-2表达同此位点多态性也无明显关联。
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| 关 键 词： | 乳腺癌 PTEN基因 单核苷酸多态性 |
Association between PTEN polymorphisms and breast cancer |
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| ZHAO Zhonghua , CHEN Shaoshui , DONG Xinjun , NING Fangling , LI Mianli , DANG Chengxue. Association between PTEN polymorphisms and breast cancer[J]. Journal of Modern Oncology, 2012, 20(7): 1347-1349 |
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| Authors: | ZHAO Zhonghua CHEN Shaoshui DONG Xinjun NING Fangling LI Mianli DANG Chengxue |
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| Affiliation: | 1Department of Oncology,The Affiliated Hospital of Binzhou Medical College,Shandong Binzhou 256603,China;2Department of Oncosurgery,The First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi Xi’an 710061,China. |
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| Abstract: | Objective:To investigate the association between the PTEN-9C/G is a SNP(single nucleotide polymorphism) polymorphism and breast cancer.Methods: We conducted a population-based case-control study in 210 breast cancer patients and 210 healthy controls.The genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results: There was no significant association between the risk of breast caner and PTEN-9C /G polymorphisms(P=0.862).There was no significant association between PTEN-9C /G polymorphisms and ER,Her-2 of breast cancer(P>0.05).Conclusion:No significant association was oberservd between breast cancer and PTEN-9C /G polymorphism. |
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| Keywords: | breast cancer PTEN gene single nucleotide polymorphism |
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