The Effect of Adrenaline,Insulin and Hydrocortisone on Human Peripheral Blood Lymphocytes Studied by Cell Surface Markers |
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Authors: | B. Eriksson E. Hedfors |
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Abstract: | Changes in numbers of peripheral blood lymphocytes from healthy individuals were calculated from samples collected before and after parenteral administration of adrenaline, insulin and hydrocortisone, respectively. A marked increase in circulating lymphocytes was noted in response to adrenaline and insulin. However, subpopulation analysis showed a decrease in the proportion of T-lymphocytes, estimated as cells forming rosettes with sheep red blood cells after incubation in the cold and a corresponding increase in proportion of lymphocytes having receptors for C3 (non-T lymphocytes). In contrast, lymphocyte numbers were unaffected by hydrocortisone. The results indicate that a decreased proportion of circulating T-lymphocytes and an increase of non-T lymphocytes may be the result of adaptive changes in response to various forms of stress and hence is to be expected in several clinical conditions. |
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Keywords: | cell surface markers hormonal effects lymphocyte subpopulations |
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