2015-2019年度国家自然科学基金中医药学科糖尿病及并发症领域资助情况及热点分析＊

目的 通过对2015-2019 年度国家自然科学基金（国自然,National Natural Science Foundation of China,NSFC）中医、中药、中西医结合学科糖尿病及并发症领域项目资助情况进行分析,有助于指导申报者了解中医药学科糖尿病及其并发症基础研究热点及资助方向。方法 检索NSFC 2015-2019年度中医学H27、中药学H28、中西医结合学H29三个学科的获资助项目,提取申报代码、项目类型、项目名称、获资助金额、批准年度、负责人及依托单位等信息录入EXCEL,利用定量分析的方法对资助情况、依托单位、项目负责人情况、研究方向分布、疾病谱分布进行分析,其次以“糖尿病”为目标进行检索、提取,对目标项目的主题词进行人工提取,通过BDP数据平台进行统计并且对提取的主题词进行词云分析。结果 共检索到目标项目374项,三个学科在此期间资助总数、获资助金额总体呈上升趋势,项目依托单位以中医药高校、科研机构为首,在糖尿病并发症中以肾病为主,研究方向中中医学学科以作用机制为研究重点,主要围绕信号通路、细胞自噬、非编码RNA、肠道菌群、线粒体等热点展开,中药学学科以作用机制、物质基础为研究重点,主要围绕信号通路、胰岛素抵抗、肠道菌群、细胞自噬、代谢组学等热点展开,中西医结合学学科以作用机制为研究重点,主要围绕信号通路、糖代谢、细胞自噬、非编码RNA、肠道菌群、炎症等热点展开。结论 糖尿病及并发症属于重大疾病范畴,中医药干预具有优势,从临床实际需求出发,紧扣研究前沿,使用新技术及新方法开展研究是近年来国家自然科学基金中医药学科糖尿病及并发症领域的资助重点。

Analysis of the Situation and Research Hotspots of Diabetes and Complication Field in TCM Projects Supported by the National Natural Science Foundation of China from 2015 to 2019

Objective To guide applicants to understand the basic research direction of diabetes, by analyzing the funding status of the National Natural Science Foundation of China (NSFC) on diabetes and complications in the 2015-2019 year.Methods We retrieved the NSFC 2015-2019 sponsored projects in the three disciplines of Chinese Medicine H27, Chinese Pharmacy H28, and Integrative Chinese and Western Medicine H29, and extracted the application code, project type, project name, funded amount, approval year, person in charge and supporting unit, etc. The information was entered into EXCEL, and the quantitative analysis method was used to analyze the funding situation, the supporting unit, the situation of the project leader, the distribution of research directions, and the distribution of the disease spectrum. Manual extraction was carried out for subject words. Statistics were carried out through the BDP data platform and word cloud analysis was performed on the extracted subject words.Results A total of 374 target items were retrieved. Three subjects were funded during the period, and the total amount of subsidy was on the rise. The project was supported by Chinese medicine universities and research institutes. The main cause of diabetic complications was nephropathy. The research direction of Chinese medicine was focused on the mechanism of action, mainly around signal transduction, autophagy, non-encoding RNA, intestinal flora, mitochondria and other hot spots. The discipline of traditional Chinese medicine focused on the action mechanism and material basis, mainly focusing on the hot spots such as signal pathway, insulin resistance, intestinal flora, autophagy and metabolomics. The discipline of integrated traditional Chinese and Western medicine focused on the action mechanism, mainly focusing on signal pathway, glucose metabolism, autophagy, non-coding RNA, intestinal flora inflammation and other hot spots.Conclusion Diabetes and complications are a major disease category. TCM intervention has the advantage. Starting from the clinical practical needs, closely studying the frontier, using new technologies and new methods to carry out research is the focus of funding of the National Natural Science Foundation in recent years.