Metabolomics Deciphering Therapeutic Effects andMechanism of Traditional Chinese Medicines |
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| Authors: | Wei-Wei M Ai-Hua Zhang Hui Sun Xiang-Cai Meng Xi-Jun Wang |
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| Affiliation: | a.National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center,Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of ChineseMedicine, Heping Road 24, Harbin 150040, China.b.School of Pharmacy, Heilongjiang University of Chinese Medicine, Heping Road, Harbin, China.,a.National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center,Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of ChineseMedicine, Heping Road 24, Harbin 150040, China.,a.National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center,Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of ChineseMedicine, Heping Road 24, Harbin 150040, China.,a.National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center,Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of ChineseMedicine, Heping Road 24, Harbin 150040, China. and a.National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center,Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of ChineseMedicine, Heping Road 24, Harbin 150040, China. |
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| Abstract: | ![]()
Traditional Chinese medicine(TCM),an ancient medical system,has the advantages of multi-targeting and multi-ingredient preparations,and is different from modern pharmacology.However,because of the complexity of TCM and the limitation of present investigation method,the research for deciphering the scientific basis and systematic features of TCM is difficult to go further.Metabolomics has a significant increased study in recent years and enables mapping of early biochemical changes in disease and hence provides an opportunity to develop predictive biomarkers.Moreover,its method and design resemble those of traditional Chinese medicine.Therefore,it can provide useful tools for exploring essence of TCM,and will help to in-depth understand Chinese medicine syndromes.In this mini-paper,particular attention will be paid to the past successes in applications of robust metabolomics to contribute to small metabolites discovery in TCM development. |
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| Keywords: | Metabolomics Biomarkers Metabolites Traditional Chinese medicine Syndromes |
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