| 食管癌旁上皮p53及增殖细胞核抗原的表达 |
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| 引用本文： | 陶仪声,承泽农,武世伍,宗永生.食管癌旁上皮p53及增殖细胞核抗原的表达[J].蚌埠医学院学报,2002,27(3):189-190. |
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| 作者姓名： | 陶仪声 承泽农 武世伍 宗永生 |
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| 作者单位： | 1. 蚌埠医学院,病理学教研室,安徽,蚌埠,233003;2. 中山医科大学,病理学教研室,广东,广州,510089 |
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| 基金项目： | 美国中华医学会资助项目;; |
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| 摘 要： | 目的:研究食管癌旁上皮p53和增殖细胞核抗原(PCNA)的表达及意义.方法:用免疫组化法检测32例食管正常黏膜上皮、124例增生上皮及120例不典型增生上皮中p53和PCNA的表达.结果:正常食管黏膜上皮中无p53的积聚.增生上皮及不典型增生上皮中p53积聚率分别是55%和79%,二者之间差异有显著性(P＜0.01).PCNA的50%的阳性率分别是0.8%和31.7%,差异亦有显著性(P＜0.01).结论:p53的改变在上皮癌变前即已存在.p53积聚及PCNA可能成为判断食管上皮为癌前病变的客观标准之一.
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| 关 键 词： | 食管肿瘤 癌前状态 增生 癌 鳞状细胞 p53 增殖细胞核抗原 |
| 文章编号： | 1000-2200(2002)03-0189-02 |
| 修稿时间： | 2001年12月30日 |
Expression of p53 and proliferating cell nuclear antigen on esophageal paracancerous epithelium |
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| TAO Yi sheng,CHENG Ze nong,WU Shi wu,ZONG Yong sheng.Expression of p53 and proliferating cell nuclear antigen on esophageal paracancerous epithelium[J].Journal of Bengbu Medical College,2002,27(3):189-190. |
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| Authors: | TAO Yi sheng CHENG Ze nong WU Shi wu ZONG Yong sheng |
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| Abstract: | Objective:To investigate the expression of p53 and proliferating cell nuclear antigen(PCNA) in esophageal paracancerous epithelium and its significance.Methods:Esophageal paracancerous epithelium were tested for p53 and PCNA using immunohistochemical technique.Results:The positive stain were not found in normal epithelium.The p53 accumulation rates in hyperplasia and dysplasia were 55% and 79%( P <0.01).PCNA immunostain positive cell increased in number from hyperplasia to dysplasia.Conclusions:p53 protein accumulation occurs early in the pathogenesis of esophageal cancer.p53 accumulation and PCNA may serve as an indicator of malignancy in human esophageal epithelium. |
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| Keywords: | esophageal neoplasms precancerous condition hyperplasia carcinoma squamous cell p53 PCNA |
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