| 异种脱钙骨基质及其释放系统的实验研究 |
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| 引用本文： | 林贵德 柯新华. 异种脱钙骨基质及其释放系统的实验研究[J]. 第三军医大学学报, 1989, 11(5): 371-374 |
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| 作者姓名： | 林贵德 柯新华 |
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| 作者单位： | 大坪医院骨科(林贵德，柯新华)，大坪医院骨科(王民刚) |
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| 摘 要： | 异种脱钙骨基质(HDBM)及其释放系统(DS)的实验研究旨在提高HDBM诱导成骨的成功率。实验用小公牛长骨干制成HDBM,加DS-CaCl_2或CaSO_4+Na_2HPO_4+KH_2PO_4移植到家兔尺骨1.5cm缺损内。经观察,X-线照片的骨钙化影出现率除CaCl_2组16、20周外可达100％,组织学为100％的新生骨形成。作者认为:HDBM及DS诱导成骨好的原因是CaCl_2或CaSO_4中Ca~(++)与Na_2HPO_4、KH_2PO_4可促进HDBM中BMP加速释放的结果。
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| 关 键 词： | 诱导成骨 脱钙骨基质 释放系统 |
An Experimental Study on HDBM and Its Dilivery System |
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| Lin Guide,et al.. An Experimental Study on HDBM and Its Dilivery System[J]. Acta Academiae Medicinae Militaris Tertiae, 1989, 11(5): 371-374 |
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| Authors: | Lin Guide et al. |
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| Abstract: | This experiment is- carried by using the long bone shafts of ox prepared for the heterogenous decalcified bone matrix(HDBM) and adding the delivery system (CaCl2 or CaSO4+Na2HPO4+KH2PO4), implanted into the 1.5 cm defect of the rabbit ulna. Except the CaCl2 group in 16 w and 20 w all the implanted bone matrix shows 100% calcified shadows and the new bone formation is 100% identified histologically. The author belived that the cause of the excellent bone induction osteogenesis of HDBM and its DS in CaCl2 or CaSo4, was the results of Ca++ with Na2HPO4 and KH2PO4 to enhanced and accelerated BMP dilirery in HDBM. |
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| Keywords: | induction osteogenic heterogenic decalcified bone matrix dilivery system |
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