Synthesis and antimycobacterial evaluation of 3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamide analogues |
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| Authors: | Ahsan Mohamed Jawed Samy Jeyabalan Govinda Khalilullah Habibullah Bakht Mohamed Afroz Hassan Mohd Zaheen |
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| Affiliation: | aNew Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan 301 030, India;bDepartment of Pharmaceutical Sciences, National Institute of Medical Sciences University, Jaipur 303 121, India;cDepartment of Pharmaceutical Chemistry, College of Pharmacy in Al-Kharj University, P.O. Box 11323, Saudi Arabia;dDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi 110 062, India |
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| Abstract: | ![]()
In the present investigation, a series of 3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamide analogues were synthesized and were evaluated for antitubercular activity by two fold serial dilution technique. All the newly synthesized compounds showed low to good inhibitory activities against Mycobacterium tuberculosis H37Rv and multi-drug resistant M. tuberculosis (MDR-TB). 3-(4-fluorophenyl)-N-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamide (4c) was found to be the most promising compound active against M. tuberculosis, H37Rv and MDR-TB with minimum inhibitory concentrations 0.83 μM and 3.32 μM respectively. |
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| Keywords: | Pyrazolines Antitubercular agents Mycobacterium tuberculosis Multi-drug resistant tuberculosis |
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