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Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression
Affiliation:1. Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;2. Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;3. Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;4. Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;5. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;6. Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;7. Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;8. Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA;9. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;10. Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;11. The Human Pancreas Analysis Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA, https://hpap.pmacs.upenn.edu/;12. Department of Surgery, University of Pennsylvania Perelman, School of Medicine, Philadelphia, PA 19104, USA
Abstract:
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  • Keywords:epigenetics  T cell development  3D genome organization  type 1 diabetes  non-obese diabetes mouse  enhancers  HiChIP  pancreas  genome folding  chromatin
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