| 透皮促进剂对白花前胡甲素体外经皮渗透的影响 |
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| 引用本文： | 张贤华,串星星,洪晓翔,金梅花,朱铉,洪颖,孟飞宏.透皮促进剂对白花前胡甲素体外经皮渗透的影响[J].中国新药杂志,2012(8):926-930. |
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| 作者姓名： | 张贤华 串星星 洪晓翔 金梅花 朱铉 洪颖 孟飞宏 |
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| 作者单位： | 厦门大学附属中山医院演武分院药剂科;厦门大学药学院;延边大学医学部基础医学院生物化学与分子生物学教研室 |
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| 基金项目： | 厦门市科技计划项目(3502Z20103009);厦门市科技计划项目(3502Z20093012) |
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| 摘 要： | 目的:考察透皮促进剂对白花前胡甲素(dl-praeruptorin A,Pd-Ia)体外经皮渗透的影响。方法:采用改进的Franz扩散池,以大鼠离体皮肤为渗透屏障,用高效液相色谱法对Pd-Ia进行含量测定,考察月桂氮酮(Azone)及1%Azone与不同浓度丙二醇(PG)混合物对Pd-Ia透皮吸收的影响。结果:使用Azone对Pd-Ia有促透作用,1%Azone效果较好,平均渗透速率达到4.064μg.cm-2.h-1;1%Azone与15%PG合用促透效果最好,平均渗透速率达到4.889μg.cm-2.h-1,且与单用1%Azone有显著性差异(P<0.05)。结论:1%Azone与15%PG合用时,含0.5%Pd-Ia溶液体外渗透具有最大促透效果,体现出协同作用。
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| 关 键 词： | 白花前胡甲素 经皮渗透 促进剂 月桂氮酮 丙二醇 |
Influence of penetration enhancers on in vitro transdermal permeation of dl-praeruptorin A |
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| ZHANG Xian-hua,CHUAN Xing-xing,HONG Xiao-xiang,JIN Mei-hua,ZHU Xuan,HONG Ying,MENG Fei-hong.Influence of penetration enhancers on in vitro transdermal permeation of dl-praeruptorin A[J].Chinese Journal of New Drugs,2012(8):926-930. |
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| Authors: | ZHANG Xian-hua CHUAN Xing-xing HONG Xiao-xiang JIN Mei-hua ZHU Xuan HONG Ying MENG Fei-hong |
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| Institution: | 1 Department of Pharmacy,Yanwu Branch Zhongshan Hospital,Xiamen University,Xiamen 361005,China; 2 School of Pharmaceutical Science,Xiamen University,Xiamen 361005,China; 3 College of Basic Medical Science,Health Science Center,Yanbian University,Yanji 133002,China) |
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| Abstract: | Objective: To study the effect of penetration enhancers on the in vitro transdermal permeation of dl-praeruptorin A(Pd-Ia) through rat skin.Methods: The permeation experiments were evaluated by Franz diffusion cell in excised rat skin.HPLC-UV method was established to determine the concentration of Pd-Ia in receptor compartment.Azone or 1% Azone combined with propylene glycol(PG) as chemical penetration enhancers were applied to study the skin permeation rates of Pd-Ia.Results: 1% Azone alone achieved the highest penetration rate,4.064 μg·cm-2·h-1.1% Azone combined with 15% PG was the best penetration enhancer with the maximal penetration rate of 4.889 μg·cm-2·h-1.Conclusion: Combination of 1% Azone with 15% PG is effective on transdermal permeation of Pd-Ia in vitro,and the combination exerts a synergistic effect. |
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| Keywords: | dl-praeruptorin A(Pd-Ia) transdermal penetration enhancers Azone propylene glycol(PG) |
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