Alcoholic Liver Damage is Provoked by 4-Methylpyrazole, which Prolongs the Influence of Ethanol but Reduces Acetaldehyde Levels |
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| Authors: | Kai O Lindros PhD Pentti Sipponen MD Pekka Pikkarainen MD Ulla Turunen MD Mikko Salaspuro MD |
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| Institution: | Research Laboratories of the State Alcohol Monopoly (Alko), Helsinki, Finland;the Jorvi Hospital, Department of Pathology, Espoo, Finland;and the Second Department of Medicine, University of Helsinki, Finland. |
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| Abstract: | Rats chronically fed ethanol developed liver injury only if they also received low doses of the alcohol dehydrogenase inhibitor, 4-methylpyrazole, suggesting that the consistency of the influence of ethanol and its metabolism, rather than the level of acetaldehyde or the degree of the metabolic effects, contributes to the pathogenesis of alcoholic liver damage. |
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