| 降压治疗与脑卒中二级预防:脑卒中后降压治疗研究 |
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| 引用本文： | 王增武,刘力生,龚兰生,张宇清,Lutgarde Thijs,Jan A.Staessen,王继光. 降压治疗与脑卒中二级预防:脑卒中后降压治疗研究[J]. 高血压杂志, 2010, 0(4) |
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| 作者姓名： | 王增武 刘力生 龚兰生 张宇清 Lutgarde Thijs Jan A.Staessen 王继光 |
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| 作者单位： | 中国医学科学院北京协和医学院阜外心血管病医院;上海交通大学医学院上海瑞金医院高血压研究所;the Studies Coordinating Centre;Division of Hypertension and Cardiovascular Rehabilitation;Department of Cardiovascular Diseases;University of Leuven; |
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| 摘 要： | 目的评价对于中国患者脑血管病后降压治疗是否可以预防脑卒中再发。方法采取双盲、安慰剂对照的试验方法,将患者随机分入对照组(n=2825)和干预组(吲达帕胺2.5 mg/d,n=2840)。一级终点事件为致死或非致死性再发脑卒中,二级终点事件为主要的致死或非致死心血管病事件。结果平均收缩压和舒张压分别为153.8和92.8 mm Hg。在随访中期(第2年),干预组收缩压/舒张压较对照组平均下降了6.8/3.3 mm Hg。干预组总共有159例再发脑卒中,对照组为219例(干预组HR=0.70;95%CI0.57～0.86;P<0.01)。干预组有199例发生心血管病事件,对照组为258例(HR=0.74;95%CI0.62～0.89;P=0.002)。结论吲达帕胺降压治疗可以降低中国人脑血管病患者再发脑卒中和心血管病事件。
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| 关 键 词： | 降压治疗 血压 脑卒中 二级预防 |
Lowering Blood Pressure for Prevention of Stroke Recurrence:A Clinical Trial of China |
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| Abstract: | Objective To determine whether blood pressure(BP) reduction prevents secondary stroke in Chinese patients with prior cerebrovascular diseases in China.Methods Patients,in a double-blind,placebo-controlled trial,were randomized into two groups: 2825 patients received a placebo and 2840 patients received 2.5 mg of indapamide daily.The primary outcomes was the recurrence of fatal or nonfatal strokes and secondary outcomes was major fatal and nonfatal cardiovascular events,respectively.Results The average systo... |
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| Keywords: | Antihypertensive treatment Blood pressure Stroke Secondary prevention |
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