EZH2与胃癌相关性的研究进展

胃癌是全球常见的恶性肿瘤之一，严重威胁着人类的生命健康。胃癌进展是由端粒酶激活、抑癌基因失活和癌基因激活等引发的，多因素、多阶段及多基因变异的综合病变过程。用于胃癌诊断及预后和疗效预测的特异性生物学标记物对于提高胃癌患者的生活质量起着重要作用。果蝇zeste基因增强子同源物2（EZH2）是果蝇zeste基因增强子的人类同源基因。近年来的多项研究发现，EZH2在胃癌组织中的表达水平高于正常组织，具有不可忽视的促进胃癌发生、发展的作用，对于提高胃癌的检出率和治疗效果均有着潜在的临床价值。本文就EZH2与胃癌相关性的研究进展作一综述。

Progress in relationship between EZH2 and gastric cancer

Gastric cancer is one of the most common malignancies in the world. It has continued to be a threat to human life. The progress of gastric cancer is a muhi-factor,multi-stage and multi-gene mutation process induced by activation of telomerase, tumor suppressor gene inactivation, oncogene activation and so on. Specific biological markers, diagnosing and predicting patients＇ survival and treatment response, play a role in improving the quality of life for gastric cancer patients. EZH2 gene, enhancer of zeste homolog 2, is a human homolog gene of the drosophila zeste gene enhancer. A number of studies in recent years have found that the expression level of EZH2 in gastric carcinoma is significantly higher than that in normal tissue. It plays an important role in the development of gastric cancer and has a potential clinical value for improving the detection rate and treatment of gastric cancer. This paper summarizes re- search progress of the correlation between EZH2 and gastric cancer.