Bone morphogenetic protein 4 inhibits cell proliferation and induces apoptosis in glioma stem cells |
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| Authors: | Zhou Zhimin Sun Lihua Wang Yingyi Wu Zhifeng Geng Jiong Miu Weifeng Pu Yi You Yongping Yang Zhengxiang Liu Ning |
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| Affiliation: | Department of Neurosurgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, People's Republic of China. |
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| Abstract: | ![]()
Glioma stem cells (GSCs), which are originated from transformed neural stem cells, are tumor-initiating cells of glioma, the most common primary malignant neoplasm of the central nervous system. Extensive studies have shown that bone morphogenetic protein 4 (BMP4) plays an important role in the differentiation and proliferation of neural stem cells. To seek the functions and mechanisms of BMP4 in GSCs, GSCs isolated from U87 human glioma cells by using vincristine were exposed to BMP4 protein. This study shows that BMP4 inhibited U87 GSC proliferation (p?
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