基于因子分析的痛风病病机研究

目的：探讨痛风病无症状性高尿酸血症期、急性关节炎期和间歇期中医证素分布情况，总结归纳痛风病的病机。方法：本研究通过对100例无症状性高尿酸血症期患者、69例痛风急性期患者和72例痛风间歇期患者进行中医证候问卷调查，应用因子分析多元统计分析方法归纳各期证素分布情况。结果：无症状性高尿酸血症期的主要证素为湿热证（36％）、阴虚证（30％）、痰湿证（19％）、气虚证（9％）及阳虚证（6％）。急性关节炎期主要证素为痰湿证（29％）、湿热证（26．1％）、阴虚证（23．2％）、阳虚证（11．6％）、血瘀证（7．2％）及气虚证（2．9％）。间歇期主要证素为阴虚证（36．1％）、湿热证（23．6％）、阳虚证（18．1％）、痰湿证（15．3％）、气虚证（9％）。结论：痛风为虚实夹杂之讧，早期及急性期以痰湿热为主，反复发作，病情迁移，则正虚加重，以阴虚、阳虚为主。

Study on Pathogenesis of Gout Based on Factor Analysis

Objective：To explore the distribution of syndrome elements during asymptomatic hyperuricemia phase of gout, urarthritis phase and intermission phase of gout, so as to conclude the pathogenesis of gout. Methods ： Questionnaire survey on TCM syndrome was conducted on 100 patients on the phase of asymptomatic hyperuricemia, 69 patients on urarthritis phase and 72 patients on intermission phase of gout. Factor analysis was adopted for the distribution of syndrome elements. Results ：The major syndrome elements of asymptomatic hyperuricemia of gout were dampness heat syndrome （ 36% ） , yin deficiency syndrome （ 30% ） , phlegm dampness syndrome （19%）, qi deficiency syndrome （9%） , yang deficiency syndrome （6%）. The major syndrome elements of urarthritis were phlegm dampness syndrome （29%）, dampness heat syndrome （26.1% ）, yin deficiency syndrome （23.2%）, yang deficiency syndrome （11. 6% ）, blood stasis syndrome （7.2%） and qi deficiency syndrome（2.9% ）. The major syndrome elements of intermission phase of gout were yin deficiency syndrome （36.1% ）, dampness heat syndrome （23.6%）, yang deficiency syndrome （18.1% ）, phlegm dampness syndrome （15.3%）, qi deficiency syndrome （9%）. Conclusion： Gout is mixed with deficiency and excess. The major syndromes of early and acute stage of gout are phlegm, dampness and heat. It is repetitive and easy to transfer to yin deficiency and yang deficiency.