益肾汤配合西药治疗IgA肾病伴高血压36例

目的:观察益肾汤配合西药治疗IgA肾病(IgAN)伴高血压的临床疗效。方法:将收治的IgAN伴高血压患者71例按入院顺序的奇数、偶数分为治疗组36例和对照组35例,所有患者均给予相同的对症支持治疗,同时口服洛汀新降压、泼尼松防治肾衰竭;治疗组另外给予自拟益肾汤治疗,疗程结束后对比观察肾功能的改善效果。结果:治疗后2组患者血压平稳,尿蛋白定量、尿沉渣红细胞计数、血肌酐水平均较治疗前有显著改善,治疗组优于对照组(P<0.05);治疗组不良反应发生率显著低于对照组(P<0.05)。结论:益肾汤配合西药治疗IgAN伴高血压疗效肯定,且能够降低西药的不良反应发生率。

Yishen Decoction Combined with Western Medicine in Treating 36 Patients with IgA Nephropathy with Hypertension

Objective：To observe Yishen decoction combined with Western medicine in the treatment of patients with IgA nephropathy （IgAN） and hypertension. Methods ： Seventy-one hospitalized IgAN patients with hypertension were divided to treatment group （ n = 36） and control group （ n = 35 ） according to order of admission. All patients were given the same symptomatic treatment and lotensin orally to prevent renal failure; Treatment group took yishen decoction in addition. Renal function was examined after treatment. Results：Blood pressure stabled after treatment; urine protein quantitative, red cell counts in urine residue, creatine level had significantly improved than before treatment, the treatment group was better than the control group （ P 〈 0. 05 ） ; adverse reaction occurrence rate was signifi- cantly lower than control groups （ P 〈 0. 05 ）. Conclusion： Yishen decoction combined with western medicine in the treatment of IgAN with hypertension can reduce the incidence of adverse reactions of western medicine.