Zoapatle. XII. In vitro effect of kaurenoic acid isolated from Montanoa frutescens and two derivatives upon human spermatozoa |
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| Authors: | A Valencia A Wens H Ponce-Monter N Pedrón A J Gallegos L Quijano J Calderón F Gómez T Ríos |
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| Affiliation: | 1. Instituto de Ciencias Agropecuarias y Rurales, Universidad Autónoma del Estado de México, Instituto Literario 100, col. Centro, C.P. 50000 Toluca, Estado de México, Mexico;2. Centro de Investigación en Recursos Bióticos, Facultad de Ciencias, Universidad Autónoma del Estado de México, Km 14.5, carretera Toluca-Atlacomulco, C.P. 50200 Toluca, Estado de México, Mexico;2. Department of Psychology, University of British Columbia, Vancouver, BC, Canada;1. GEMMA – Group of Environmental Engineering and Microbiology, Department of Civil and Environmental Engineering, Universitat Politècnica de Catalunya BarcelonaTech, c/Jordi Girona 1-3, Building D1, E-08034, Barcelona, Spain;2. UCIBIO-REQUIMTE, Department of Chemistry, Faculty of Sciences and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal.;1. Treatment Centre For Traumatic Injuries, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China;2. Department of Pharmaceutical, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China;3. School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510080, China;4. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China |
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| Abstract: | ![]()
Zoapatle aqueous crude extract (ZACE) from Montanoa tomentosa has been used as an oral contraceptive in traditional Mexican medicine for centuries. Kaurenoic acid, as isolated from Montanoa frutescens, and the methyl esters of 15-hydroxy-dihydro-kaurenoic acid and 15-keto-dihydro-kaurenoic acid were tested in vitro on human sperm motility and viability. The estimated ED50 concentrations immobilization were 374, 126 and 58 micrograms/ml, respectively using 15 X 10(6) sperms/500 microliter. Kaurenoic acid and both of its derivatives displayed only weak to negligible capacity for killing human sperms. |
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