~(89)Sr治疗骨转移癌疼痛研究

 目的　评价放射性核素89锶 (89Sr)对骨转移癌的止痛疗效和不良反应 ,并探讨其在癌性骨痛治疗中的应用范围。方法　观察 35例骨转移癌患者使用89Sr治疗后的止痛疗效、肿瘤标记物水平的变化、不良反应及血液学毒副反应。结果　89Sr止痛总有效率为 71 .4 % ,其中来源于前列腺癌和乳腺癌的骨转移癌患者有效率达到 80 .0 %。少数肿瘤标记物水平有下降。副反应主要为轻度可逆性的骨髓造血功能损害。89Sr对血生化无明显不良影响。结论　89Sr是治疗骨转移癌疼痛的一种安全有效的方法

A study on pain relief of malignant bone metastasis with 89Sr radionuclide therapy

Objective The aims were to evaluate the effectiveness of pain relief and toxicity of the 89 Sr radionuclide therapy for bone metastatic cancer and preliminarily determine the indication for pain relief of malignant bone metastasis. Methods The effect of pain relief, the level of tumor markers and the side effects of 35 cases of bone metastatic cancer were observed. The blood routine and blood biochemistry were tested. Results The total response rate was 71.4% , while the response rate of bone metastasis originated from prostatic cancer and breast cancer was 80.0% .The levels of tumor markers in a few cases reduced slightly. The mild reversible decrease of white blood cells,hemoglobin and platelets were the main side effect. 89 Sr had little effect on blood biochemistry. Conclusion 89 Sr radionuclide therapy was an effective and well tolerated method on bone metastatic cancer.