| 人脐带间充质干细胞治疗移植物抗宿主病的临床观察 |
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| 引用本文： | 文钦,陈幸华,高蕾,张曦,张诚,高力,曾韫璟,孔佩艳,刘红,彭贤贵. 人脐带间充质干细胞治疗移植物抗宿主病的临床观察[J]. 中国输血杂志, 2012, 25(2): 123-126 |
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| 作者姓名： | 文钦 陈幸华 高蕾 张曦 张诚 高力 曾韫璟 孔佩艳 刘红 彭贤贵 |
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| 作者单位： | 第三军医大学新桥医院血液科全军血液病中心,重庆,400037 |
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| 基金项目： | 第三军医大学新桥医院临床科研课题资助项目(2011D262、2010D249) |
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| 摘 要： | 目的探讨人脐带间充质干细胞(UCMSCs)在急性移植物抗宿主病(aGVHD)中的疗效及安全性。方法40名对激素无效的aGVHD患者分为两组,UCMSCs组:接受他克莫司+甲氨蝶呤(MTX)+UCMSCs抗GVHD治疗,常规治疗组:仅接受他克莫司+MTX治疗。结果 UCMSCs组治愈率及治疗有效率均高于常规治疗组(P0.05)。UCMSCs组治疗组及常规治疗组治疗起效的平均时间分别为(16.15±6.34)d、(20.8±6.94)d,(P0.05);治愈的平均时间分别为(25.5±7.18)d、(30.4±8.07)d,(P0.05)。UCMSCs组无1例因感染死亡。UC-MSCs组在输注UCMSCs过程中没有出现不良反应。UCMSCs及常规治疗组发生aGVHD各2例,无1例本病复发。讨论UCMSCs治疗aGVHD有效、安全。
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| 关 键 词： | 人脐带间充质干细胞 急性移植物抗宿主病 造血干细胞移植 |
Observation on humam umbilical cord-mesencnymal Stem Cell for the Treatment of acute graft versus host disease after Hematopoietic Stem Cell Transplantation |
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| WEN Qin , CHENG Xinghua , GAO Lei , ZHANG Xi , ZHANG Cheng , GAO Li , ZENG Wenjing , KONG Peiyan , LIU Hong , PENG Xiangui. Observation on humam umbilical cord-mesencnymal Stem Cell for the Treatment of acute graft versus host disease after Hematopoietic Stem Cell Transplantation[J]. Chinese Journal of Blood Transfusion, 2012, 25(2): 123-126 |
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| Authors: | WEN Qin CHENG Xinghua GAO Lei ZHANG Xi ZHANG Cheng GAO Li ZENG Wenjing KONG Peiyan LIU Hong PENG Xiangui |
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| Affiliation: | .Department of Hematology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China |
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| Abstract: | Objective To evaluate the efficacy and safety of human umbilical cord mesenchymal Stem Cell(UCMSCs) for the treatment of acute graft versus host disease(aGVHD).Methods Forty patients with aGVHD were divided into two groups.Twenty patients received treatment with tacrolimus,methotrexate and UCMSCs.Twenty patients received treatment with tacrolimus and methotrexate.Results The recovery rate and effective power of UCMSCs-group is higher than the other group(P<0.05).The initial action time of UCMSCs-group and the other group is(16.15±6.34)days and(20.8±6.94)days,respectively(P>0.05).The time to complete remission of UCMSCs-group and the other group is(25.5±7.18)d and(30.4±8.07)d,respectively(P<0.05).No patient died of infection in UCMSCs-group.there is no adverse reaction during the infusion of UCMSCs.There are two Patients with aGVHD in UCMSCs-group and two in the other group.The recurrence of the disease is never occur in the both groups.Conclusion The infusion of UCMSCs is an effective and safe treatment for aGVHD. |
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| Keywords: | Humam umbilical cord-mesenchymal Stem Cell acute graft versus host disease Hematopoietic Stem Cell Transplantation |
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