| 自体纯化CD34~+细胞移植治疗中/高危淋巴细胞来源恶性肿瘤的临床研究 |
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| 引用本文： | 曾韫璟,高力,陈幸华,张曦,高蕾,张诚,文钦,孔佩艳,刘红,彭贤贵. 自体纯化CD34~+细胞移植治疗中/高危淋巴细胞来源恶性肿瘤的临床研究[J]. 中国输血杂志, 2012, 25(2): 120-122 |
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| 作者姓名： | 曾韫璟 高力 陈幸华 张曦 高蕾 张诚 文钦 孔佩艳 刘红 彭贤贵 |
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| 作者单位： | 第三军医大学新桥医院血液科全军血液病中心,重庆,400037 |
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| 基金项目： | 国家自然科学基金(81070388);重庆市自然科学基金重点项目(2009BA5056);第三军医大学临床科研基金(2010D249) |
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| 摘 要： | 目的分析自体纯化CD34+细胞移植治疗中/高危淋巴细胞来源恶性肿瘤的临床疗效。方法 10名中/高危组淋巴细胞来源恶性肿瘤患者行自体纯化CD34+细胞移植治疗,细胞分选采用cliniMACS系统。计算并统计分选纯度和CD34+细胞回收率,观察移植相关并发症及患者生存情况。结果纯化后CD34+细胞纯度为(87.79±3.73)%,回收率达到(65.74±10.37)%。10名患者全部顺利造血重建,感染发生率50%(5/10例),复发率为20%(2/10例)。结论利用CliniMACS系统进行外周血CD34+细胞分选,CD34+细胞纯度、回收率均满意,自体移植后造血功能重建顺利,近期疗效满意。
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| 关 键 词： | CD+细胞 自体 移植 肿瘤 临床疗效 |
Purified autologous CD34+ cell transplantation for the treatment of Medium/High Risk lymphocytic malignancies |
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| ZENG Wenjing , GAO Li , CHENG Xinghua , ZHANG Xi , GAO Le , ZHANG Cheng , WEN Qin , KONG Peiyan , LIU Hong , PENG Xiangui. Purified autologous CD34+ cell transplantation for the treatment of Medium/High Risk lymphocytic malignancies[J]. Chinese Journal of Blood Transfusion, 2012, 25(2): 120-122 |
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| Authors: | ZENG Wenjing GAO Li CHENG Xinghua ZHANG Xi GAO Le ZHANG Cheng WEN Qin KONG Peiyan LIU Hong PENG Xiangui |
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| Affiliation: | .Deparment of Hematology,Xinqiao Hospital,Third Micitary Medical Mniuersity,Chongqing 400037,China |
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| Abstract: | Objective To study the effectiveness of CD34+ selected autologous peripheral blood stem cell transplantation(APBSCT) in medium/high risk lymphocytic malignancies.Methods 10 patients received autologous CD34+ selected APBSCT,purified by CliniMACS device.The sorting purity and recovery of CD34+ cells were calculated.Transplant-related complications and prognosis were observed.Results After selection,the mean recovery of CD34+ cells was(65.74±10.37)% and the mean purity was(87.79±3.73)%.All 10 patients achieved hematopoietic recovery successfully.The rates of infectiou and relapse were 50%(5/10),and 20%(2/10),respectively.Conclusion Peripheral blood CD34+ selection and purification using CliniMACS system are effective with satisfactory purity and recovery.Hemopoietic recovery can be achieved with good short term effectiveness. |
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| Keywords: | CD34+ Cell Autologous Transplantation Lymphocyte Clinic effect |
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