铜绿假单胞菌的临床分离和药敏情况分析

目的分析铜绿假单胞菌的临床分离和药敏情况,指导临床合理使用抗生素。方法对本院2016年1月~2017年10月临床分离的524株铜绿假单胞菌采用统一的方法、设备和判断标准进行耐药性检测,使用WHONET5.6进行数据分析。结果铜绿假单胞菌耐药率在50%以上的抗生素包括复方新诺明、阿莫西林/克拉维酸、氯霉素、头孢噻肟、四环素、氨苄西林、呋喃妥因和头孢唑啉,敏感性高于70%的抗生素包括头孢他啶、哌拉西林、左旋氧氟沙星、头孢吡肟、美洛培南、环丙沙星、亚胺培南、哌拉西林/他唑巴坦、庆大霉素、阿米卡星和多粘菌素B。结论铜绿假单胞菌的耐药机制复杂,应加强对铜绿假单胞菌的临床分布及耐药性监测,指导临床合理使用抗生素,采取有效的防范措施控制医院感染,采取多种治疗策略最大限度减少铜绿假单胞菌耐药性发展。

Clinical isolation and drug susceptibility of pseudomonas aeruginosa

Objective To analyze the clinical isolation and drug susceptibility of Pseudomonas aeruginosa and to guide the rational use of antibiotics in clinic.Methods A total of 524 strains of pseudomonas aeruginosa clinically isolated from January 2016 to October 2017 in our hospital were tested for drug resistance using a uniform method,equipment and judgment criteria.And data analysis was performed using WHONET 5.6.Results Antibiotics with pseudomonas aeruginosa drug resistance rate above 50% included cotrimoxazole, amoxicillin/ clavulanic acid,chloramphenicol,cefotaxime,tetracycline,ampicillin,nitrofurantoin and cefazolin.Antibiotics with sensitivity greater than 70% included ceftazidime, piperacillin, levofloxacin, cefepime, meropenem, ciprofloxacin,imipenem,piperacillin/tazobactam,gentamicin,amikacin and polymyxin B.Conclusion The mechanisms of drug resistance monitoring of pseudomonas aeruginosa are complicated.The clinical distribution and drug resistance of Pseudomonas aeruginosa should be strengthened to guide the rational use of antibiotics in clinic.Effective preventive measures should be taken to control nosocomial infections and various treatment strategies should be taken to minimize the development of pseudomonas aeruginosa drug resistance.