地特胰岛素联合瑞格列奈治疗老年2型糖尿病的临床疗效观察

目的观察地特胰岛素联合瑞格列奈治疗老年2型糖尿病的临床疗效。方法选取2016年1月~2017年1月我院收治的老年2型糖尿病患者100例,采用随机数字表法随机分为两组,每组各50例,对照组应用地特胰岛素进行治疗,观察组同时联合瑞格列奈治疗,观察疗程8周。观察两组患者治疗前后空腹血糖水平、餐后2h血糖水平、糖化血红蛋白(HbA1c)的变化情况,并对两组治疗后的临床疗效进行评价。结果观察组的临床总有效率显著高于对照组(P0.05)。观察组患者的FPG、2hPG、HbA1c水平均明显低于对照组,差异具有统计学意义(P0.05)。观察组的低血糖发生率显著低于对照组(P0.05)。结论地特胰岛素联合瑞格列奈治疗老年2型糖尿病临床疗效确切,安全性好,值得临床广泛推广和应用。

Observation of the clinical efficacy of insulin detemir combined with repaglinide in the treatment of senile type 2 diabetes mellitus

Objective To observe the clinical efficacy of insulin detemir combined with repaglinide in the treatment of senile type 2 diabetes mellitus.Methods A total of 100 patients with senile type 2 diabetes mellitus who were admitted to our hospital from January 2016 to January 2017 were selected.The patients were randomly divided into two groups according to the method of random number table,with 50 patients in each group.The control group was given insulin detemir,and the observation group was given repaglinide.The course of treatment was 8 weeks.The changes of the levels of fasting blood glucose,postprandial 2 h blood glucose and glycosylated hemoglobin(HbA1c)were observed before and after treatment in both groups,and the clinical efficacy of the two groups after treatment was evaluated.Results The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).The levels of FPG,2hPG and HbA1c in the observation group were significantly lower than those in the control group,and the differences were significant(P<0.05).The incidence rate of hypoglycemia in the observation group was significantly lower than that in the control group(P<0.05).Conclusion The clinical efficacy of insulin detemir combined with repaglinide in the treatment of senile type 2 diabetes mellitus is effective and safe,which is worthy of widespread clinical popularization and application.