神经节苷脂、高压氧、亚低温治疗新生儿缺氧缺血性脑病的疗效观察

目的比较三种新生儿缺氧缺血性脑病治疗方案(神经节苷脂、高压氧、亚低温)与常规治疗方案的疗效差异,为临床选择治疗方案提供依据。方法选择新生儿缺氧缺血性脑病120例,随机分为常规治疗组、神经节苷脂治疗组、高压氧治疗组和亚低温治疗组,每组各30例。观察对比上述三种治疗方案的有效率及总有效率与常规治疗组的差异。结果神经节苷脂、高压氧、亚低温治疗组有效率分别为93.3%,86.7%,80.0%,疗效显著优于常规治疗组有效率60.0%(P0.05)。结论神经节苷脂、高压氧、亚低温治疗新生儿HIE疗效优于常规治疗组,均可作为新生儿HIE的治疗方案,具有一定的临床意义。

Ganglioside,hyperbaric oxygen,curative effect observation of cryogenic treatment of neonatal hypoxic ischemic encephalopathy

Objective The aim of our study was to investigate the effect of gangliosides,hyperbaric oxygen,mild hypothermia on the outcome of neonatal hypoxic ischemic encephalopathy（ HIE）. Methods 120 cases of neonatal HIE patients were randomly divided into three groups： conventional treatment group,gangliosides treatment group,hyperbaric oxygen treatment group and mild hypothermia group（ n = 30 in each group）. The efficiency of these treatments and outcome of neonatal HIE patients were evaluated. Results According to the outcome,the efficacy of gangliosides,hyperbaric oxygen and mild hypothermia treatment group were 93. 3%,86. 7%,80. 0%,respectively. The ratio of therapeutic effect in the treated groups was significantly higher than that of conventional treatment group 60. 0%（ P 〈 0. 05）. Conclusion Our study demonstrated that gangliosides,hyperbaric oxygen and mild hypothermia could significantly improve the outcomes of patients with HIE,which might be used as clinical treatments of neonatal IE.