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Body fat distribution is associated with lumbar spine bone density independently of body weight in postmenopausal women
Authors:Saarelainen J  Honkanen R  Kröger H  Tuppurainen M  Jurvelin J S  Niskanen L
Affiliation:a Bone and Cartilage Research Unit, Clinical Research Center, University of Eastern Finland, P. O. Box 1627, 70211 Kuopio, Finland;b Research Institute of Public Health, University of Eastern Finland, P. O. Box 1627, 70211 Kuopio, Finland;c Department of Applied Physics, University of Eastern Finland, P. O. Box 1627, 70211 Kuopio, Finland;d Department of Orthopaedics and Traumatology and Handsurgery, Kuopio University Hospital, P. O. Box 1777, 70211 Kuopio, Finland;e Department of Gynaecology and Obstetrics, Kuopio University Hospital, P. O. Box 1777, 70211 Kuopio, Finland;f Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, P. O. Box 1777, 70211 Kuopio, Finland;g Department of Medicine, Kuopio University Hospital, P. O. Box 1777, 70211 Kuopio, Finland
Abstract:

Objective

To assess the association between the body fat distribution and axial bone mineral density (BMD) in postmenopausal women with or without hormone replacement therapy (HRT).

Design

Cross-sectional population-based study.

Setting

University of Eastern Finland, Bone and Cartilage Research Unit, Kuopio, Finland.

Population

198 postmenopausal women, mean age 67.5 (1.9 SD), mean BMI 27.1 (3.9 SD).

Methods

Regional body composition and BMD assessed by dual X-ray absorptiometry (DXA, Prodigy).

Main outcome measures

Spinal and Femoral BMD.

Results

Out of the body composition parameters, FM was the main determinant of postmenopausal bone mass. Only the lumbar spine (L2–L4) BMD, not the femoral neck BMD, was positively associated with the trunk FM. Positive trends for association were revealed between the spinal BMD and the trunk FM regardless of the use of HRT. Adjustments did not change the results.

Conclusions

Higher trunk fat mass was associated with the spinal BMD, but not with the hip BMD in postmenopausal women, irrespective of the HRT use. In addition to biological factors, uncertainties related to DXA measurements in patients with varying body mass may contribute to this phenomenon.
Keywords:Body composition   Fat mass   Hormone replacement therapy (HRT)   Dual-energy X-ray absorptiometry (DXA)   Menopause
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