首页 | 本学科首页   官方微博 | 高级检索  
     


CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation
Authors:Takeshita Keisuke  Yamasaki Tsugiko  Nagao Koichi  Sugimoto Hiromi  Shichijo Michitaka  Gantner Florian  Bacon Kevin B
Affiliation:Bayer Yakuhin, Ltd., Research Center Kyoto, Respiratory Disease Research, 6-5-1-3, Kunimidai, Kizu-cho, Soraku-gun, 619-0216 Kyoto, Japan.
Abstract:
Chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes, CRTH2, is a cognate receptor for prostaglandin (PG) D(2) and, in humans, is suggested to play a functional role in Th2-dependent allergic inflammation. While peripheral blood leukocytes expressing high levels of surface CRTH2 have been detected in disease, little is known of the functional significance of CRTH2 in disease etiology. We have utilized a Th2-dependent murine model of FITC-induced contact hypersensitivity to assess the role, if any, CRTH2-PGD(2) may play in the elicitation or maintenance of such pathobiology. Expression of both PGD(2) and CRTH2 in lesional skin was paralleled by the release of the chemoattractants LTB(4) and the chemokine KC, as well as a profuse dermal neutrophilic and eosinophilic infiltrate, closely paralleling the acute inflammatory pathology observed in human atopic dermatitis. A small molecule CRTH2 antagonist, but not a selective PGD(2)R (DP) receptor antagonist, was able to completely abrogate these responses. Inflammatory cascades mediated by CRTH2 ligation may therefore represent an important early step in the elicitation and maintenance of Th2-dependent skin inflammation.
Keywords:chemokines   hypersensitivity   inflammation   leukocytes   prostanoids   skin
本文献已被 PubMed Oxford 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号