清洁肠道对烧伤后肠源性高代谢的影响

目的　探讨烧伤后是否存在“肠源性高代谢”及清洁肠道对其的影响。方法　在建立严重烧伤加清洁肠道动物模型的基础上 ,将 96只Wistar大鼠随机分为烧伤对照 (B)组和烧伤加清洁肠道 (C)组。观察了伤后 0～ 1 0d大鼠静息能量代谢率 (REE)的变化 ,同时检测了伤后 1、3、5、7、1 0d血中内毒素 (LPS)、肿瘤坏死因子 (TNF)和白细胞介素 1 (IL 1 )的含量 ,并进行相关分析。结果　烧伤后两组大鼠的REE、TNF、LPS和IL 1均明显高于伤前 ,两组相比 ,C组的REE、TNF、LPS和IL 1较B组均有不同程度的降低。相关分析显示 ,REE同LPS、TNF和IL 1呈显著正相关 (r1 =0 77,P <0 0 5;r2 =0 81 ,P <0 0 5 ;r3=0 90 ,P <0 0 1 )。结论　烧伤后存在肠源性高代谢 ,清洁肠道可降低血中炎症介质含量 ,从而降低高代谢反应

Effects of cleaning intestine on enterogenous hypermetabolism after severe burn injury in rats

Objective To explore whether the enterogenous hypermetabolism is present or not, and the effects of cleaning intestine on it after burn injury. Methods Ninety six Wistar rats were inflicted with 30% total body surface area full thickness burns and randomly divided into 2 groups: namely burned control (B) and cleaned intestine after burn (C) group. The following indices including the resting energy expenditure (REE), plasma levels of LPS, TNF and IL 1 were determined. Results After burn injury, the REE, TNF, LPS and IL 1 were significant increased. Comparing with B group, the level of REE, TNF, LPS and IL 1 were decreased in different degrees. Correlation analyses showed that REE had a positive correlation to LPS, plasma levels of TNF and IL 1 ( r 1=0.77, P <0.05; r 2=0.81, P <0.05; r 3=0.90, P <0.01). Conclusion The results show that there indeed exists enterogenous hypermetabolism after burn injury. Cleaning intestine can reduce the hypermetabolic reaction after burn injury by decreasing the contents of inflammatory media in the blood.