降压合剂对胰岛素抵抗高血压大鼠作用效应及机制的实验研究

目的观察降压合剂对胰岛素抵抗高血压大鼠的作用效应，探讨其作用机制。方法雄性SD大鼠饲以高糖高盐饲料制模，然后分组给予不同药物灌胃，观察各组大鼠体重、收缩压(SBP)、空腹血糖(FBG)、空腹血胰岛素(FINS)、胰岛素敏感性指数(ISI)、红细胞Na

Experimental study on theeffects and mechanism of Jiangy a mixture(

Objective:To observe the effects of Jiangya mixture(JYM,降压合剂) on insulin resistance hy pertensive rat model and investigate its mechanism.Methods:Male Spraque Darley rats were fed on high glucos e and high salt diet to establish experimental model,following by giving differe nt drugs to divided groups.The changes in body weig ht(BW),systolic blood pressure(SBP),fasting blood glucose(FBG),fasting blood ins ulin(FINS),insulin sensitivity index(ISI),red blood cell(RBC) Na＋ K＋ATPase,angiotensinⅡ(AgⅡ) were observed.Results:(1)At fourth week,SBP and FINS were increased but ISI decrea sed in rats fed on high glucose and high salt diet(all P<0.01).(2)At ei ghth week in comparison with normal group the activity of RBC Na＋ K＋ATPase was decreased but AgⅡ increased (all P<0.05)in model gro up.In Comparison with model group the SBP,FBG and FIN S were decreased,otherwise ISI was increased (P<0.05 or P<0.01).In o ther groups,meanwhile the activity of RBC Na＋K＋ATP JYM+capto pril group and AgⅡ decreased (P<0.05) in captop ril group.Conclusions:Hypertension and insulin resistance can be ind uced in rats by feeding high glucose and high salt diet .The JYM can reduce blood pressure,blood sugar,and level of blood insulin other wise increase insulin sensitivity.The mechanisms of it on reducing blood pressur e and increasing insulin sensitivity may be obtained by heightening the activit ies of Na＋K＋ATPase.