| 嗅鞘细胞促进大鼠坐骨神经损伤后神经功能恢复 |
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| 引用本文： | 吴银生,王冠华,徐华梓,池永龙. 嗅鞘细胞促进大鼠坐骨神经损伤后神经功能恢复[J]. 浙江创伤外科, 2011, 16(6): 721-725 |
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| 作者姓名： | 吴银生 王冠华 徐华梓 池永龙 |
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| 作者单位： | 1. 温州市中西医结合医院, 温州,325003
2. 温州医学院附属第二医院 |
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| 摘 要： | 目的研究嗅鞘细胞（Olfactory ensheathing cells,OECs）移植对大鼠坐骨神经损伤后神经再生恢复的作用。方法取SD大鼠40只随机分成对照生理盐水（SAL）组和实验（OECs）组,予离断坐骨神经后直接予神经外膜缝合修复,在神经缝合处周围充填可吸收的明胶海绵,SAL组和OECs组明胶海绵内分别给予SAL和体外培养纯化的OECs;术后4、12周分别行大体观察,电生理检查和组织学检查。结果术后4、12周,SAL组和OECs组修复神经均有不同程度恢复,OECs组在运动神经传导速度、神经肌肉动作电位幅度和直径数据上有优于SAL组,但统计学上未见明显差异,而在有髓神经纤维数目方面明显优于SAL组（P〈0.05）。结论在本实验条件下,嗅鞘细胞（OECs）对大鼠坐骨神经损伤后的神经功能恢复有部分的促进作用。
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| 关 键 词： | 嗅鞘细胞 细胞移植 坐骨神经 神经再生 |
Olfactory ensheathing cells enhance functional recovery of injured sciatic nerve in rat |
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| WU Yinshen,WANG Guanhua,XU Huazhi,et al.. Olfactory ensheathing cells enhance functional recovery of injured sciatic nerve in rat[J]. Zhejiang Journal of Traumatic Surgery, 2011, 16(6): 721-725 |
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| Authors: | WU Yinshen WANG Guanhua XU Huazhi et al. |
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| Affiliation: | WU Yinshen,WANG Guanhua,XU Huazhi,et al.Integrated Chinese and Western Medicine Hospital of Wenzhou,Zhejiang 325003,China |
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| Abstract: | Objective To investigate the effect of olfactory ensheathing cells(OECs) on functional recovery after sciatic nerve injury in rat.Methods Thirty SD rats were randomly divided into two groups(SAL group and OECs group).The sciatic nerve was repaired by epineurium suturation after sciatic nerve mutilation.Gelatin sponge was filled around the sciatic nerve suture.Purified olfactory ensheathing cells(OECs) or saline(SAL) were injected into the gelatin sponge respectively.On 4,12 weeks after sciatic nerve injury,... |
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| Keywords: | Olfactory ensheathing cells Cell transplantation Sciatic nerve Nerve regeneration |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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