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Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I |
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| Authors: | Fillet Anne-Marie Auray Laetitia Alain Sophie Gourlain Karine Imbert Berthe Marie Najioullah Fatiha Champier Gael Gouarin Stéphanie Carquin Jocelyne Houhou Nadhira Garrigue Isabelle Ducancelle Alexandra Thouvenot Danielle Mazeron Marie-Christine |
| Affiliation: | Virology Laboratories, Hospital AP-HP Pitié-Salpêtrière and University Paris VI, Paris, France. anne-marie.fillet@psl.ap-hop-paris.fr |
| Abstract: | We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions. |
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