| 抗病毒中药1号在MDCK细胞中对流感病毒B的抑制作用 |
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| 引用本文： | 杨怡姝,李洪源,刘密凤,刘电力,周昆,佟奎明.抗病毒中药1号在MDCK细胞中对流感病毒B的抑制作用[J].黑龙江医学,2001,25(1):16-17. |
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| 作者姓名： | 杨怡姝 李洪源 刘密凤 刘电力 周昆 佟奎明 |
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| 作者单位： | 哈尔滨医科大学公共卫生学院流行病学教研室 |
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| 摘 要： | 目的 为了解抗病毒 1号单味中草药对流感病毒B的抑制作用。方法 本研究采用细胞培养技术 ,以病毒唑为阳性对照药 ,观察抗病毒 1号对流感病毒的抑制作用。结果 抗病毒 1号半数中毒浓度(TC50 )为 60 53mg/ml ;治疗和预防给药方式均有抗流感病毒作用 ,其抗流感病毒B的半数有效浓度 (EC50 )分别为 8 88mg/ml和 9 2 1mg/ml ;治疗指数 (TI)分别为 6 81和 6 57。结论 抗病毒 1号对流感病毒B的抑制作用存在着明显的量效关系。
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| 关 键 词： | 流感病毒 抗病毒作用 中草药 |
| 文章编号： | 1004-5775(2001)01-0016-02 |
| 修稿时间： | 2000年9月6日 |
Anti-influenza Effect of a Chinese Medicinal Herb-No.1 in MDCK C ulture |
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| YANG Yi-shu,LI Hong-yuan,LIU Mi-feng,et al.Anti-influenza Effect of a Chinese Medicinal Herb-No.1 in MDCK C ulture[J].Heilongjiang Medical Journal,2001,25(1):16-17. |
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| Authors: | YANG Yi-shu LI Hong-yuan LIU Mi-feng |
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| Abstract: | Objective: To observe the anti-influenza effect of a Chinese medicinal herb-Antiviral Agent No.1. Methods: The cell culture technique with Ribavirin was used as positive control to observe the anti-influenza effect. Results: This drug was found to be a potential inhibitor of influenza B virus in a concentration-dependent manner with a TC50 of 60.53mg/ml in MDCK culture. The EC50 (TI) was 8.88mg/ml when drug was added 2 hours after virus infection. The EC50 (TI) was 9.21mg/ml while drug was added 2 hours before infection. Conclusion: There might be a quantity-effect relation between the Chinese medicinal herb-No.1 and it's inhibiting action to influenza virus B. |
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| Keywords: | Influenza virus Antiviral effect Chinese medicinal herb |
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