抗耐甲氧西林金黄色葡萄球菌天然药物研究进展

以抗耐甲氧西林金黄色葡萄球菌(Methicillin-resistant Staphylococcus aureus,MRSA)天然药物为对象,检索了近年来对其天然药物研究的相关文献,并进行归纳整理。来源于植物、动物、微生物的能有效抗MRSA的化合物,包括植物中的黄酮类、萜类、蒽醌类等,动物中的抗菌肽及毒素,以及部分微生物的代谢产物等。部分化合物可作为未来抗MRSA的候选药物。目前抗MRSA的天然药物研究已经成为该领域的研究热点之一,但是多数研究仅停留在对活性药物的筛选上,缺少对候选药物的毒理、药理等深入研究。

Research progress in natural medicine on anti-methicillin-resistant Staphylococcus aureus

To review the latest progress in study on the natural medicine on anti-methicillin-resistant Staphylococcus aureus (MRSA), the relevant literatures on the natural medicine against MRSA are summarized. It is found that, in recent years, a series of compounds derived from plants, animals, and microorganisms were reported showing the anti-MRSA activities, such as flavonoids, terpenoids, and anthraquinones from plants, antimicrobial peptides and toxins from animals, and some microbial metabolites, which could be developed as the candidate drug in future. Currently, the study on anti-MRSA of natural medicine has become one of the hotspots in this article, but most research only stays in screening active drugs, lacking further in-depth study about the toxicology, pharmacology and other mechanisms of these candidate drugs.