Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil |
| |
| Authors: | MJ Kauppi,HA Savolainen,V-J Anttila,HA Isomä ki |
| |
| Affiliation: | Rheumatism Foundation Hospital, Heinola and Third Department of Medicine1, Helsinki University Hospital, Helsinki, Finland |
| |
| Abstract: | Two cases of acute leukaemia have developed in a group of 77 patients treated with chlorambucil (Chl) because of severe juvenile chronic arthritis. The total follow-up from the beginning of Chl treatment in these patients was 560 years, indicating a highly increased risk of leukaemia. Despite favourable results, especially in patients with secondary amyloidosis, Chl should only be used in selected cases. |
| |
| Keywords: | Chlorambucil cytotoxic drugs juvenile chronic arthritis leukaemia |
|
|
