Effect of dextran on the stability of isolated, perfused rat heart |
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| Authors: | T Okada |
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| Affiliation: | Department of Physiology, Juntendo University School of Medicine, Tokyo, Japan. |
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| Abstract: | Stability of cardiac function and myocardial intracellular ionic composition was examined in the Krebs-perfused isolated rat working heart. Hearts perfused by a conventional Krebs solution showed stable contraction for 2 h, but during this period, intracellular ionic environment (Na, K, Ca) substantially changed. Addition of dextran to the perfusate inhibited, though not completely, this time-dependent deterioration and made the heart less vulnerable to the hypoxia-reoxygenation. |
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