不同方法治疗婴幼儿社区获得性肺炎临床研究

目的探讨婴幼儿社区获得性肺炎（CAP）不同治疗方法的临床疗效和不良反应。方法100例社区获得性肺炎随机分为阿奇霉素组（A组）50例和头孢呋辛钠组（B组）50例；采用VITEK—AMS微生物分析仪测定病原菌，并用纸片法（Knby—Bauer）没定病原菌的体外药物敏感性。结果A组治疗后痊愈45例（90．0％）明显高于B组39例（78．0％）；A组退热时间（3．86±0．95）d低于B组（5．01±1．12）d；A组哕音消失时间（3．81±0．74）d低于B组（5．17±1．22）d，差异均有统计学意义（P〈0．05）。A组阳性株数44株，转阴株数39株，细菌消除率为88．6％；B组阳性株数41株，转阴株数35株，细菌消除率为85．3％；A组3例出现恶心、呕吐，不良反应发生率为6．0％（3／50），B组为8．0％（4／50），差异均无统计学意义（P〉O．05）。结论阿奇霉素是治疗婴幼儿CAP的首选药物。

Clinical Research of Infants with Community-acquired Pneumonia by Different Treatment Methods

Objective To investigate the infants with community-acquired pneumonia（CAP）of different treatment methods of clinical effica- cy and adverse reactions. Methods 100 cases of community-acquired pneumonia were randomly divided into azithromycin group（A group） 50 cases and eefuroxime sodium group （B group ） 50 eases ; using VITEK-AMS microbiological analysis to measure the pathogens, and use disk diffusion method （Kirby-Bauer）Determination of pathogenic bacteria in vitro drug sensitivity. Results A group after treatment cured 45 cases （90.0%）was significantly higher than the B group of 39 eases（78.0%）（ χ 2=3.98 ,P〈0.05） ;The time in A group defervescence（3.86 ＋ 0.95）days less than the B group（5.01 ± 1.12）days（t=2.416, P〈0.05）;The time rales disappearance in group A（3.81 ± 0.74）days less than B group （5.17 ± 1.22）days（ t= 2.396, P〈0.05 ）;The positive in group A of 44 strain, turin negative in 39 strain, bacterial eradication rate was 88.6%; The positive in group B 41 strain,turin negative in 35 strain,bacterial eradication rate was 85.3%,A,B groups of bacteria elimination was no significant difference （χ 2=2-98,P〉0-05） ;The incidence of adverse reactions of nansea,vomifing in group A of 3 eases 6.0%（3/50）;B group was 8.0% （4/50）（ χ 2= 2.23, P〉 0.05 ）. Conclusion The drug of Azithromycin were preferred with treatment in infants and young with CAP.