慢性低氧大鼠肾上腺皮质球状带的变化

将Ｗｉｓｔａｒ大鼠喂养在逐渐降低的常压低氧条件下，用氮气和空气的混合气体调节氧含量。氧浓度由正常逐步降低为１５％、１２％、１０％、８％，最后降至７％，实验共进行１１２ｄ，结果显示低氧动物体重下降，肾上腺重量减少，肾上腺皮质球状带萎缩，脂质丢失，球状带细胞线粒体肿胀和空泡变性，溶酶体增多，表明在慢性常压低氧中，当吸入气氧含量降至７％时，可导致肾上腺皮质球状带细胞超微结构改变，从而影响醛固酮的合成与分

CHANGES IN THE ZONA GLOMERULOSA OF ADRENAL CORTEX OF RATS CHRONICALLY EXPOSED TO HYPOXIA

Rats were exposed to chronic normobaric hypoxia of progressively increasing severity;via 15%,12%,10%,and 8% down to 7% oxygen concentrations.The hypoxic experiment continued for 112 days.The results showed that chronic hypoxia caused body weight loss and decrease of adrenal weight,atrophy and lipid loss of the zona glomerulosa,swelling and vacuolation of mitochondria,and increase of lysosomes.These findings indicated that as oxygen concentration of inspiratory in the chronic normobaric hypoxia is down to 7%,it induced ultrastructural changes of glomerulosa cells and influenced the synthesis and secretion of aldosterone.