阿立哌唑对精神分裂症患者血清催乳素的影响

目的探讨阿立哌唑对精神分裂症患者血清催乳素的影响。方法选取60例精神分裂症患者,随机分为阿立哌唑组和利培酮组,分别给予阿立哌唑和利培酮治疗8周,在治疗前及治疗后2、4、8周末采用阳性与阴性症状量表（PANSS）对两组进行评定,并于治疗前、治疗后4周末、8周末采用放射免疫法测查PRL水平。结果两组PANSS量表评分治疗8周末均比治疗前极显著减少（P〈0.01）,但两组间相比差异无统计学意义（P〉0.05）;治疗前后阿立哌唑组PRL水平比较差异无统计学意义（P〉0.05）,利培酮组治疗8周末PRL水平明显升高（P〈0.05）;出现月经紊乱或泌乳阿立哌唑组较利培酮组明显为少（P〈0.05）。结论阿立哌唑对精神分裂症患者有较好的疗效,对PRL的影响较小,是一种有效而安全的新型抗精神病药物。

A controlled study of effect on schizophrenia serum prolactin level aripiprazole

Objective To explore the in fluence of aripiprazole on schizophrenia serum prolactin level. Methods 60patients with schizophrenia were randomly divided into aripiprazole group （ n = 30） and risperidone group （ n = 30） for 8 weeks. The positive and negative synodrome scale （ PANSS ） was evaluated before and after 2,4,8 weeks. The PRL level was measured by radioimmunoassay Before,at the end of 4 week and 8 week. Resuits At the end 8th week, there were the most reduced significantly in the scores of PANSS between two groups than before evaluated （ P 〈 0. 01 ） , but compared of two groups was no significant differences （ P 〉 0. 05 ） ; There was no significant difference in serum level of PRL before and after treatment in aripiprazole group（ P 〉 0. 05 ）. However, the serum level of PRL increased highly after risperidone treatment（ P 〈 0. 05 ）. Compared with patients in risperidone group （7/18,38.9%） , patients in aripiprazole group seldom had menstruation dysfunction and lactation（ P 〈 0. 05 ）. Conclusion Aripiprazole is better effective in the treatment of patients With schizophrenia ,with less influence on serum PRL level. Aripiprazole is one of effective and safe drugs in the treatment of schizophrenia.