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Effect of administration of diethylcarbamazine with and without fluconazole on experimental fungal infections in mice |
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| Authors: | Kitchen L W Ross J A Hernandez J E Zarraga A L Mather F J |
| Affiliation: | a Section of Infectious Diseases, Marshall University School of Medicine and Veterans Administration Medical Center, Huntington WV, USA b Department of Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, New Orleans, LA, USA |
| Abstract: | Other researchers have found that diethylcarbamazine (DEC) is effective treatment for filariasis despite a lack of demonstrated in vitro antifilarial activity. The results of our previous investigations using feline and murine leukemia virus models encouraged us to investigate the use of DEC with other infections. In our current experiments, DEC treatment was associated with lower brain fungal burden in fluconazole-treated mice following intravenous injection of Aspergillus fumigatus or increasing numbers of Cryptococcus neoformans organisms, and lower brain and kidney levels of Candida albicans following intravenous injection of increasing numbers of C. albicans. Further investigation of combined DEC and fluconazole treatment of fungal infections is warranted. |
| Keywords: | Diethylcarbamazine Biological response modifiers Retrovirus HIV Fungal mouse models Fluconazole Antifungal drugs Opportunistic infections |
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