瘦素与急性胰腺炎的相关性研究

目的检测急性胰腺炎（AP）患者血清中瘦素和TNF-α浓度,探讨瘦素与急性胰腺炎及体重指数的关系。方法采用放射免疫法（RIA）检测20例急性胰腺炎患者的血清瘦素和TNF-α的水平,并分析其意义,对照组为37例肥胖者。结果在病例组中,瘦素水平明显高于对照组（P〈0.05）,血清瘦素水平与TNF-α、BMI均没有相关（P〉0.05）;在对照组中,血清瘦素水平与TNF-α、BMI均呈正相关（P〈0.05）。结论AP患者血清瘦素水平显著高于正常健康肥胖者;AP患者血清瘦素含量的增加可能来源于胰腺的释放;血清瘦素是急性胰腺炎生物学指标之一,对损伤的胰腺具有保护作用。

Measurement of serum leptin level in acute pancreatitis patients

Objective To detect serum levels of leptin and TNF-α and evaluate its clinical significance in acute pancreatitis （AP） and BMI （body mass index）.Methods The serum leptin level and TNF-α were detected by RIA in a total of 20 AP patients.37 obese persons were included in the study as a control group.Results Serum leptin level was significantly higher in AP patients than the control group （p〈0.05）.No correlation was observed between the serum level of leptin,TNF-α and BMI in AP patients （p〉0.05） and a positive correlation was observed in the control group （p〈0.05）.Conclusion Leptin is one of the biological indicators,which has protective effect on AP.Leptin in AP is probably derived from the inflamed pancreas.