|
|||||
|
|
| 短程兰索拉唑、克拉霉素和阿莫西林三联疗法根除幽门螺杆菌在东南亚患者中的疗效——5日一日三次疗法和7日一日两次疗法 | |
| 基金项目： | 马来西亚政府IRPA研究项目 |
| 摘 要： | 目的:测定和比较含兰索拉唑、克拉霉素和阿莫西林的5日tid疗法和7日bid疗法根除幽门螺杆菌(H.pylori)的疗效.方法:本研究为随机、双盲、对照研究.胃窦和胃体部活检经组织学检查和快速尿素酶试验确诊为H.pylori感染的患者纳入研究.患者分别接受克拉霉素500 mg tid、阿莫西林500 mg tid和兰索拉唑每日30 mg治疗5天(LAC5组)或克抗雷素500 mg bid、阿莫西林500 mg bid和兰索拉唑每日30 mg治疗7天(LAC7组).治疗结束至少4周后,用组织字检应查和快速尿素酶试验评估H.Pylori是否成功根除,胃窦和胃体部活检H.Pylori阴性定义为H.Pylori根除.结果:108例患者纳入研究.LAC5组有4例患者失访;LAC7组2例患者失访,2例患者对药物不能依从.按意图治疗分析,LAC5组的根除率为85.2%[46/54,95%可信区间(CI):72.9%,93.4%],LAC7组的根除率为87.0%(47/54,95%CI:75.1%,94.6%);按方案分析,LAC5组的根除率为92.0%(46/50,95%CI:80.8%,97.8%),LAC7组的根除率为94.0%(47/50,95%CI:83.5%,98.7%).两种疗法对患者均很适宜,除LAC7组2例外,其余患者均服完规定的药物.两种疗法的副作用均较轻微,没有患者因对药物不耐受而中断治疗.最常见的副作用是味觉改变(LAC5组:64.7%,LAC7组:78.8%).少数患者有腹泻、恶心和厌食.结论:LAC5 tid疗法和LAC7 bid疗法均为具有良好耐受性的治疗方案,根除H.Pylori的疗效高. |
| 关 键 词： | 螺杆菌,幽门 根除 超短程 兰索拉唑 克拉霉素 阿莫西林 |
The Efficacy of Short Course Lansoprazole with Clarithromycin and Amoxycillin in the Eradication of Helicobacterpylori in South East Asian Patients 5 day tid versus 7 day bid Treatment Regimen |
|
| KL Goh,PL Chean,P Ranjeev,YM Tan,M Rosmawati,KT Ong,YL Lo,SC Chin. The Efficacy of Short Course Lansoprazole with Clarithromycin and Amoxycillin in the Eradication of Helicobacterpylori in South East Asian Patients 5 day tid versus 7 day bid Treatment Regimen[J]. Chinese Journal of Gastroenterology, 2000, 5(4) | |
| Authors: | KL Goh PL Chean P Ranjeev YM Tan M Rosmawati KT Ong YL Lo SC Chin |
| Affiliation: | 1. Department of Medicine,Faculty of Medicine, Universitv of Malaya, Malavsia 2. Department of Pathology,Faculty of Medicine, Universitv of Malaya, Malavsia 3. Department of Surgery,Faculty of Medicine, Universitv of Malaya, Malavsia 4. Pharmacy, University Hospital,Faculty of Medicine, Universitv of Malaya, Malavsia 5. GI Research Unit, Faculty of Medicine, Universitv of Malaya, Malavsia |
| Abstract: | |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ | |