| 微波诱变头孢菌素C产生顶头孢霉菌的研究 |
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| 引用本文： | 桑庆华,梁景乐,宋爱刚,白芳静,史宁,蒋涛. 微波诱变头孢菌素C产生顶头孢霉菌的研究[J]. 齐鲁药事, 2007, 26(10): 615-616 |
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| 作者姓名： | 桑庆华 梁景乐 宋爱刚 白芳静 史宁 蒋涛 |
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| 作者单位： | 山东鲁抗医药股份有限公司,山东,济宁,272100 |
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| 摘 要： | 本实验以头孢菌素C高产菌L32为出发菌株,通过微波诱变,得到变株L32-104,初复筛证明其发酵单位提高20%,且遗传性状非常稳定。该菌株在中试以及大生产中均获成功。实验表明微波诱变法操作简便、安全可靠、方法可行。
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| 关 键 词： | 头孢菌素A 顶头孢霉 微波诱变 |
| 文章编号： | 1672-7738（2007）10-0615-02 |
Study of microwave mutagenesis on selection of Cephalosporin C production strain-Cephalosporium acremonium |
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| SANG Qing-hua,LIANG Jing-le,SONG Ai-gang,BAI Fang-jing,SHI Ning,JIANG Tao. Study of microwave mutagenesis on selection of Cephalosporin C production strain-Cephalosporium acremonium[J]. qilu pharmaceutical affairs, 2007, 26(10): 615-616 |
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| Authors: | SANG Qing-hua LIANG Jing-le SONG Ai-gang BAI Fang-jing SHI Ning JIANG Tao |
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| Affiliation: | Shandong Lukang pharmaceutical co. Ltd. ,Jining 272100 |
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| Abstract: | OBJECTIVE a mutant L32-104 was obtained by inducing Cephalosporium acremonium L32 with microwave irradiation in this experiment,and the yield increased by 15-20 percent. It showed great genetic stability through flask experiment, and pilot scale experiment and large scale experiment showed that L32-104 was a very good strain. The method is sinpie,safe and reliable. |
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| Keywords: | Cephalosporin C Cephalosporium acremonium microwave mutagenesis |
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