儿童使用布洛芬致不良反应15例回顾性分析

目的:探讨儿童使用布洛芬致不良反应(ADR)的相关因素,为临床合理用药提供参考。方法:在中国知网(CNKI)检索1986-2013年文献报道的儿童使用布洛芬致ADR病例,就收集到的15例ADR的相关情况进行回顾性分析。结果:15例ADR中,男性患儿9例(占60.00%);所有患儿均为口服给药;ADR大部分发生在首次给药后(占73.33%),最快为首次服药后2 min,最慢为服药后第5天;ADR以皮肤及其附件损害最常见(占30.43%);ADR经停药并对症治疗后均好转或恢复。结论:布洛芬是一种相对较安全的解热镇痛药,但临床应用时应充分考虑儿童的生理、病理特点,并严格按照说明书使用,以避免ADR的发生。

Retrospective Analysis of 15 Cases of ADR Induced by Ibuprofen in Children

OBJECTIVE： To investigate the related factors of adverse drug reaction （ADR） induced by ibuprofen in children, and to provide reference for rational drug use in the clinic. METHODS： 15 cases of ibuprofen-induced ADR in children collected from CNK/during 1986 to 2013 were analyzed retrospectively. RESULTS： Of 15 ADR cases, male （9 cases） showed higher proportion （60.00%）. All children were given medicine orally. Most ADR occurred after first medication （73.33%）, in which the fastest ADR occurred 2 min after administration, and the slowest ADR occurred 5 days after medication. Organs or systems involved in ADR were lesion of skin and appendents （30.43%）; ADR were cured after drug withdrawal or symptomatic treatment. CONCLUSIONS： Ibuprofen is a kind of safe drugs for analgesic-antipyretic, and physiology and pathology characteristics of children should be considered to use it strictly according to package inserts, in order to avoid ADR.