超重对高血压患者胰岛素抵抗的影响

目的 :观察超重对高血压患者胰岛素抵抗 (IR)的影响及相互间的关系。方法 :测定 2 6例高血压超重、2 6例高血压非超重者及 2 2例正常对照的空腹血糖 (SG)、胰岛素 (INS)、C肽 (CP)水平 ,计算胰岛素敏感指数 (ISI) ,并将 ISI与收缩压 (SBP)、舒张压 (DBP)、体重指数 (BMI)、年龄等指标作相关分析。结果 :高血压超重者 INS、CP较正常对照组明显增高 ,ISI明显减低 (P<0 .0 5 ) ;高血压非超重组虽有类似的改变 ,但差异没有统计学意义。多因素分析显示 ,ISI仅与 BMI显著相关。结论 :超重对 IR有一定的影响 ,可促进和加重高血压患者的 IR。

Effects of Overweight on Insulin Resistance in Patients with Hyperten- sion

Objective:To investigate the relation between overweightand insulin resistance in pa- tients with essential hypertension.Methods:Serum glucose(SG) ,insulin(INS) ,C-peptide(CP) and sensitivity index of insulin (ISI) were measured in 2 6 essential hypertensive patients with overweight,2 6 essential hypertensive patients without overweight and2 2 healthy subjects.The correlations between ISI and body mass index(BMI) ,SBP,DBP,age were analyzed.Results:SG, INS,CP were significantly increased(P<0 .0 5 ) and ISI was significantly decreased(P<0 .0 5 ) in hypertensive patients with overweight as compared with healthy subjects,whereas there was no significant difference between nonoverweight hypertensive patients and healthy subjects.ISI was correlated positively with BMI and negatively with the other parameters in hypertensive patients. Conclusion:Overweight can aggravate insulin resistance in essential hypertensive patients. Key words:Weigh gain;Hypertension/ etiol;Hyperinsulinism/ etiol;Insulin resistanceEffects of Overweight on Insulin Resistance in Patients with Hyperten- sion JING Zheng-ming,HUANG Yuan-wei.(First Affiliated H ospital,College of Medical Sciences, Zhejiang University,H angzhou 31 0 0 0 3,China) Abstract:Objective:To investigate the relation between overweightand insulin resistance in pa- tients with essential hypertension.Methods:Serum glucose(SG) ,insulin(INS) ,C-peptide(CP) and sensitivity index of insulin (ISI) were measured in 2 6 essential hypertensive patients with overweight,2 6 essential hypertensive patients without overweight and2 2 healthy subjects.The correlations between ISI and body mass index(BMI) ,SBP,DBP,age were analyzed.Results:SG, INS,CP were significantly increased(P<0 .0 5 ) and ISI was significantly decreased(P<0 .0 5 ) in hypertensive patients with overweight as compared with healthy subjects,whereas there was no significant difference between nonoverweight hypertensive patients and healthy subjects.ISI was correlated positively with BMI and negatively with the other parameters in hypertensive patients. Conclusion:Overweight can aggravate insulin resistance in essential hypertensive patients.