实体器官移植受者侵袭性真菌病的诊治近况

随着移植技术的成熟,实体器官移植(solid organ transplant,SOT)成功率显著提高。近年来,在SOT受者中侵袭性真菌病(invasive fungal disease,IFD)的发生率呈逐年上升趋势,其病死率较高,已成为SOT受者移植物带功能死亡的重要原因。由于IFD对移植成功造成极大威胁,已引起临床移植医师的高度重视。IFD治疗能否成功,取决于对IFD的早期诊断和及时有效治疗,目前相关研究多基于病例报道或回顾性分析。本文对侵袭性真菌病的危险因素、发病率、诊断及治疗进展作一综述。

Invasive fungal diseases in solid organ transplant recipients: recent progress in diagnosis and treatment

Thanks to the improvement in transplant skills and newly developed immunosuppressive agents, rejections after solid organ transplants (SOTs) have been greatly reduced and SOTs are more likely to succeed. In recent years, invasive fungal diseases (IFDs) have been increasing after SOTs and have become a major reason for recipient death with normal function of transplants, which poses a great threat to SOTs and has drawn great concern from physicians. Success management of IFD depends on early diagnosis and timely treatment. Currently available reports mainly focus on case-reports or retrospective analyses. This paper reviews the risk factors, prevalence, diagnosis and management of IFDs in SOT recipients.