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| 灰鼠耳蜗毛细胞脱氢酶活性在卡铂耳中毒时的早期变化 | |
| 引用本文： | 丁大连,王坚,胡博华,郑向阳,Richard.J.Salvi. 灰鼠耳蜗毛细胞脱氢酶活性在卡铂耳中毒时的早期变化[J]. 听力学及言语疾病杂志, 1998, 0(1) |
| 作者姓名： | 丁大连 王坚 胡博华 郑向阳 Richard.J.Salvi |
| 作者单位： | 美国纽约布法罗大学耳聋及听力学研究中心 |
| 摘 要： | 采用组织化学技术观察了灰鼠耳蜗毛细胞中脱氢酶在卡铂耳中毒早期的活性变化.发现卡铂可选择性地抑制内毛细胞中的脱氢酶活性.并且这种影响是从底回开始向顶回发展.提示在内毛细胞变性之前.卡铂可通过抑制内毛细胞的脱氢酶干扰其能量的代谢. |
| 关 键 词： | 灰鼠 内毛细胞 脱氢酶 耳中毒 卡铂 |
Carboplatin-induced Early Changes of Dehydrogenase Activity in Chinchilla Hair Cells |
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| Ding Dalian,Wang Jian,Hu Bohua.et al.. Carboplatin-induced Early Changes of Dehydrogenase Activity in Chinchilla Hair Cells[J]. Journal of Audiology and Speech Pathology, 1998, 0(1) | |
| Authors: | Ding Dalian Wang Jian Hu Bohua.et al. |
| Abstract: | Histochemical analysis was applied to observe early changes of dehydrogenase activity in the hair cells following carboplatin ototoxicity in chinchilla. The results showed that the activity of dehydrogenase in inner hair cells were particularly and immediately inhibited by carbo-platin and this effect started at the base of the cochlea first and developed at the apex later. The results indicate that energy metabolism of the inner hair cells could be disturbed before hair cell degeneration. |
| Keywords: | Chinchilla Inner hair cell Dehydrogenase Ototoxicity Carboplatin |
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